This website contains results from one of several case-control studies of psychiatric diseases done at the Broad Institute. Results of other studies are available at the following websites:
The Bipolar Exome (BipEx) sequencing project is a collaboration between multiple institutions across the globe, which aims to increase our understanding of the disease architecture of bipolar disorder.
The Epi25 collaborative is a global collaboration committed to aggregating, sequencing, and deep-phenotyping up to 25,000 epilepsy patients to advance epilepsy genetics research. The Epi25 whole-exome sequencing (WES) case-control study is one of the collaborative's ongoing endeavors that aims to characterize the contribution of rare genetic variation to a spectrum of epilepsy syndromes to identify individual risk genes.
The Schizophrenia Exome Sequencing Meta-analysis (SCHEMA) consortium is a large multi-site collaboration dedicated to aggregating, generating, and analyzing high-throughput sequencing data of schizophrenia patients to improve our understanding of disease architecture and advance gene discovery. The first results of this study have provided genome-wide significant results associating rare variants in individual genes to risk of schizophrenia, and later releases are planned with larger number of samples that will further increase power.